Meningitis: Adults > 50 years, Immunocompromised (including AIDS), Alcohol abuse, Debilitating illness, Pregnancy
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Ceftriaxone | 2g IV q12h | See Duration |
| + | ||
| Ampicillin | 2g IV q4h | |
| + | ||
| Vancomycin | 25-30mg/kg IV once then 15mg/kg IV q8-12h |
Cephalosporin allergy
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Meropenem | 2g IV q8h | See Duration |
| + | ||
| TMP/SMX | 15-20mg TMP/kg/day IV div q6-8h | |
| + | ||
| Vancomycin | 25-30mg/kg IV once then 15mg/kg IV q8-12h |
Severe penicillin, cephalosporin, and carbapenem allergy
| Empiric Therapy | Dose | Duration |
|---|---|---|
| TMP/SMX | 15-20mg TMP/kg/day IV div q6-8h | See Duration |
| + | ||
| Vancomycin | 25-30mg/kg IV once then 15mg/kg IV q8-12h |