Necrotizing fasciitis/myositis in Adults - Culture proven

- Use of IV immune globulin (1-2g/kg/day x 2 days) could be considered if streptococcal toxic shock also present.

- Invasive Group A Streptococci is reportable to Public Health.

- Prophylaxis of contacts of invasive Group A Streptococci is recommended by most Public Health experts. See Prophylaxis for Contacts of Communicable Diseases.

Therapy	Dose	Duration
Penicillin	4MU IV q4h	10-14 days
+
Clindamycin	600-900mg IV q8h	Continue until hemodynamically stable and initial debridement complete (1-3 days)

Therapy	Dose	Duration
Penicillin	4MU IV q4h	10-14 days
+
Clindamycin	600-900mg IV q8h	Continue until hemodynamically stable and initial debridement complete (1-3 days)

Therapy	Dose	Duration
Ceftriaxone	2g IV daily	10-14 days
+
Clindamycin	600-900mg IV q8h	Continue until hemodynamically stable and initial debridement complete (1-3 days)

Therapy	Dose	Duration
Cloxacillin	2g IV q4h	10-14 days
+
Clindamycin	600mg IV q8h	Continue until hemodynamically stable and initial debridement complete (1-3 days)

Therapy	Dose	Duration
Vancomycin	15mg/kg IV q8-12h	10-14 days