Duration dependent on:

• ability to remove line
• organism involved
• uncomplicated/complicated (see below).

Uncomplicated

BC positive with:

- CoNS - 5-7 days

Avoid treatment in response to single positive blood culture for CoNS. Repeat culture recommended.

- S. aureus & TEE negative - 14 days after first negative BC

- Gram negative organisms - 7-14 days

- Candida spp - 14 days after first negative BC.

- If BC negative but catheter tip ≥15 CFU of S. aureus or Candida spp, consider 5-7 day course of therapy after line removal.

Complicated

- Septic thrombophlebitis - 4-6 weeks

- Endocarditis - 4-6 weeks

- Osteomyelitis - 6-8 weeks

- Persistent bacteremia > 72h after catheter removal despite appropriate antimicrobial therapy - 4-6 weeks.