Community acquired
- If S. aureus isolated, rule out infection at a distal site, e.g. osteomyelitis or endovascular infection; longer duration of therapy required.
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Piperacillin-tazobactam | 3.375-4.5g IV q6h | 7-10 days |
Severe penicillin allergy/anaphylaxis
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Ciprofloxacin | 400mg IV q12h/500mg PO bid | 7-10 days |
| + | ||
| Vancomycin | 25-30mg/kg IV once then 15mg/kg IV q8-12h | |
| + | ||
| Metronidazole | 500mg IV/PO q12h |