Pleural effusion

Usual Pathogens

S. pneumoniae
S. aureus/MRSA
Group A Streptococci
H. influenzae
Enterobacterales

 

Empiric Therapy Dose Duration
Ceftriaxone 1-2g IV daily 2-4 weeks

If MRSA suspected/documented, add:

Empiric Therapy

Dose

Duration
Vancomycin 15mg/kg IV q8-12h 2-4 weeks
or    
Linezolid 600mg IV/PO q12h 2-4 weeks