Failure of first line agents
- persistent
- prolonged
- recurrent
- For pen (I) S. pneumoniae, amoxicillin is most active of all oral ß-lactam agents.
Usual Pathogens
S. pneumoniae
H. influenzae
M. catarrhalis
Group A Streptococci
S. aureus
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Amoxicillin-clavulanate | 875mg PO bid | 10 days |
Nonsevere penicillin allergy
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Cefuroxime axetil | 500mg PO bid | 10 days |
Severe penicillin allergy or cephalosporin allergy
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Levofloxacin | 750mg PO daily | 10 days |