Antiviral
| Antimicrobial | Normal Adult Dose | Dose and Interval Adjustment for Renal Impairment | ||
|---|---|---|---|---|
| Creatinine Clearance (mL/min) | ||||
| >50 | 10 - 50 | <10 (Anuric) | ||
| Acyclovir | 400mg PO tid | NO CHANGE NEEDED | q12h | |
| 5-10mg/kg IV q8h | q8h | 25-50mL/min: q12h 10-25mL/min: q24h |
50% dose q24h | |
| Amantadine | 100mg PO bid or 100mg PO daily | |||
| Famciclovir | 500mg PO tid | q8h | q12-24h | 250mg q24h |
| Ganciclovir |
Induction 5mg/kg IV q12h |
50-69mL/min: 2.5mg/kg q12h |
25-49mL/min: 2.5mg/kg q24h 10-24mL/min: |
1.25mg/kg 3x/week |
|
Maintenance 5mg/kg IV q24h |
50-69mL/min: 2.5mg/kg q24h |
25-49mL/min: 1.25mg/kg q24h 10-24mL/min: |
0.625mg/kg 3x/week |
|
| Oseltamivir |
Treatment 75mg PO bid |
> 60mL/min: NO CHANGE NEEDED |
> 30-60mL/min: 30mg PO bid 10-30mL/min: |
USE WITH CAUTION: 75mg PO once only |
|
Prophylaxis 75mg PO daily |
> 60mL/min: NO CHANGE NEEDED |
> 30-60mL/min: 30mg PO daily 10-30mL/min: |
USE WITH CAUTION: 30mg PO once only |
|
| Valacyclovir | 1g PO tid | q8h | q12-24h | 500mg q24h |
| Valganciclovir |
Induction 900mg PO bid |
q12h |
450mg daily- q2days |
DO NOT USE |
|
Maintenance 900mg PO daily |
daily |
450mg q2days - 2x/week |
DO NOT USE |
|
| Zanamivir | 10mg inhaled orally daily-bid | NO CHANGE NEEDED | ||