Known MRSA, injection drug use, antibiotics in past 3 months, vascular catheter, or medical device in situ
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Piperacillin-tazobactam | 3.375-4.5g IV q6h | 7-10 days |
| + | ||
| Vancomycin | 25-30mg/kg IV once then 15mg/kg IV q8-12h |
Severe penicillin allergy/anaphylaxis
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Ciprofloxacin | 400mg IV q12h/750mg PO bid | 7-10 days |
| + | ||
| Vancomycin | 25-30mg/kg IV once then 15mg/kg IV q8-12h | |
| + | ||
| Metronidazole | 500mg IV/PO q12h |