2° to immunosuppression

- Risk factors:

  • diabetic ketoacidosis
  • neutropenia.

- Surgical debridement necessary.

- Treat underlying condition.

- Consult ophthalmologist re: need for intravitreal antifungal.

 
Usual Pathogens

Mucor spp
Rhizopus spp
P. aeruginosa
S. aureus/MRSA

 

Empiric Therapy Dose Duration
Amphotericin B 0.8mg/kg IV daily; if tolerated increase up to 1.5mg/kg/d 3g total dose