Non-responders (after 72 hours of therapy) or Early relapse (2-7 days post therapy)
Group A Streptococci resistance to macrolides and clindamycin is significant.
Usual Pathogens
Group A Streptococci
Non-responders
Change in antibiotic therapy may not be required.
Early relapse
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Amoxicillin-clavulanate | 875mg PO bid | 10 days |
Alternative
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Azithromycin | 500mg PO daily | 3 days |
| or | ||
| Clarithromycin | 250mg PO bid | 10 days |
| or | ||
| Clindamycin | 300mg PO tid | 10 days |