Fractures, complex (open)
Common Pathogens
S. aureus
Coagulase negative Staphylococcus (CoNS)
Enterobacteriaceae
| Regimen(s) of Choice See General Principles and Pre-Op Antibiotic Administration and Intraoperative Antibiotic Administration | ||
|---|---|---|
| Cefazolin | 2g IV | x 1 pre-op dose |
| If MRSA colonization/past infection, add: | ||
| Vancomycin | 15mg/kg IV | x 1 pre-op dose |
| Alternative Regimens if allergy to cefazolin, or severe non-IgE-mediated reaction to any β-lactam (interstitial nephritis, hepatitis, hemolytic anemia, serum sickness, severe cutaneous reactions [e.g. SJS, TEN, DRESS]) | ||
|---|---|---|
| Clindamycin | 600mg IV | x 1 pre-op dose |
| or | ||
| Vancomycin | 15mg/kg IV | x 1 pre-op dose |
| If heavily soiled/contaminated (Grade III), add: | ||
| Gentamicin | 5mg/kg IV | x 1 pre-op dose |