Quinolones
| Antimicrobial | Normal Adult Dose | Dose and Interval Adjustment for Renal Impairment | ||
|---|---|---|---|---|
| Creatinine Clearance (mL/min) | ||||
| >50 | 10 - 50 | <10 (Anuric) | ||
| Ciprofloxacin | 250-750mg PO q12h | q12h | < 30mL/min: q24h | |
| 200-400mg IV q12h | q12h | < 30mL/min: q24h | ||
| Levofloxacin | 500mg PO/IV daily | q24h | 500mg once then 250mg q24h | 500mg once then 250mg q48h |
| 750mg PO/IV daily | q24h | 750mg q48h | 750mg once then 500mg q48h | |
| Moxifloxacin | 400mg PO/IV daily | NO CHANGE NEEDED | ||
| Norfloxacin | 400mg PO q12h | q12h | q12-24h | q24h |