S. aureus risk factors:
-
previous (prior 12 months)/current MRSA colonization or infection
-
severe/necrotizing process on CXR
-
rapid deterioration
-
coma/head injury
-
recent influenza
-
injection drug use
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Ceftriaxone | 2g IV daily | 7-10 days |
| + | ||
| Azithromycin | 500mg IV/PO daily | 3 days |
| + | ||
| Vancomycin | 25-30mg/kg IV once then 15mg/kg IV q8-12h | 7-10 days |
Cephalosporin allergy
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Levofloxacin | 750mg IV/PO daily | 7-10 days |
| + | ||
| Vancomycin | 25-30mg/kg IV once then 15mg/kg IV q8-12h |