Klebsiella variicola

Cannot be easily distinguished from K. pneumoniae but may be more virulent.

Gram Stain

• Gram negative bacilli  - fermenter

Clinical Significance

These organisms are widely distributed in nature and are part of commensal human gastrointestinal flora.

They are associated with both community and health care associated infections (pneumonia, urinary tract infections, bacteremia, septicemia, meningitis and skin/soft tissue/ bone/joint infections).

K. variicola -  associated with similar infections as K. pneumoniae.

 

Usual Susceptibility Pattern

These organisms are resistant to ampicillin.

The number of strains producing extended spectrum beta-lactamases (ESBL) or AmpC cephalosporinases is increasing, resulting in resistance to penicillins, cephalosporins, and beta-lactamase inhibitor combinations.

Carbapenem resistance is significant in certain geographic locations.

Most strains remain susceptible to aminoglycosides, quinolones, and nitrofurantoin.

Susceptibility to TMP/SMX and tetracyclines is variable. These organisms should be considered resistant to fosfomycin.

 

Empiric Therapy
Urinary Tract Infection:
TMP/SMX
or
Ciprofloxacin
Severe Infections:
Ceftriaxone