Intra-abdominal candidiasis
[Clin Infect Dis 2016;62:e1-50.]
- Risk factors for intra-abdominal candidiasis: recent abdominal surgery, anastomotic leaks, necrotizing pancreatitis.
- Source control, with appropriate drainage and/or debridement, is critical.
Usual Pathogens
Candida spp
| Empiric Therapy | Duration | |
|---|---|---|
| Fluconazole | 800mg (12mg/kg) IV loading dose then 400mg (6mg/kg) IV/PO daily | Based on adequacy of source control and clinical response. |
| or | ||
| Anidulafungin |
200mg IV once then 100mg IV daily |
Based on adequacy of source control and clinical response. |
| or | ||
| Caspofungin |
70mg IV once then 50mg IV daily |
Based on adequacy of source control and clinical response. |
| or | ||
| Micafungin | 100mg IV daily | Based on adequacy of source control and clinical response. |