Fulminant
toxic megacolon
hypotension
shock
Clostridioides difficile
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Vancomycin | 125mg PO/NG qid | 10 days |
| + | ||
| Metronidazole IV | 500mg IV q8h | Until patient is no longer critically ill (usually 5-7 days) |
If ileus, add
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Vancomycin PR | 500mg PR qid | 10 days |