Uncomplicated
- Pretreatment urine cultures recommended. Tailor antibiotics to C&S results. Do NOT use nitrofurantoin or fosfomycin as these are not systemically active.
Usual Pathogens
E. coli
Other Enterobacterales
S. saprophyticus
Outpatient - initial parenteral dose
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Ceftriaxone | 1-2g IV/IM | single dose |
| or | ||
| Gentamicin | 5-7mg/kg IV/IM | single dose |
| then |
Oral therapy
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Cefixime | 400mg PO daily | 7-10 days |
| or | ||
| Amoxicillin-clavulanate | 875mg PO bid | 7-10 days |
| or | ||
| Ciprofloxacin | 500mg PO bid or | 7 days |
| XL 1g PO daily | 7 days | |
| or | ||
| TMP/SMX | 1DS tab PO bid | 7-10 days |
ER/Hospitalized/Septic
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Ceftriaxone | 1-2g IV q24h | 7 days |
| or | ||
| Gentamicin | 5-7mg/kg IV q24h | 7 days |