Bacterial
Usual Pathogens
Polymicrobial:
Enterobacterales (especially Klebsiella spp)
Anaerobes
Streptococcus anginosus group
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Ceftriaxone | 1-2g IV daily | Dependent on adequate drainage; not to exceed 4-6 weeks) |
| + | ||
| Metronidazole IV/PO | 500mg IV/PO q12h |
Severe/ICU
Empiric Therapy |
Dose | Duration |
|---|---|---|
| Piperacillin-tazobactam | 4.5g IV q8h or | Dependent on adequate drainage; not to exceed 4-6 weeks |
| 3.375g IV q6h |
Multiple previous antibiotics/previous ceftriaxone-resistant Gram negative organism
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Meropenem | 500mg IV q6h | Dependent on adequate drainage; not to exceed 4-6 weeks) |
Penicillin and carbapenem allergy
Empiric Therapy |
Dose | Duration |
|---|---|---|
| Vancomycin | 15mg/kg IV q12h | Dependent on adequate drainage; not to exceed 4-6 weeks |
| + | ||
| Ciprofloxacin IV/PO | 400mg IV q12h/500-750mg PO bid | |
| + | ||
| Metronidazole IV/PO | 500mg IV/PO q12h |