Necrotizing enterocolitis (NEC)
- Adjust therapy based on Gram stain and/or culture, including antifungal therapy if applicable.
Usual Pathogens
Enterobacterales
Streptococcus spp
Coagulase negative Staph
Perforation add:
Anaerobes
| Empiric Therapy | Duration | |
|---|---|---|
| Vancomycin | 40-60mg/kg/d IV div q6h | 7-10 days |
| + | ||
| Cefotaxime | 150-200mg/kg/d IV div q8h |
Perforation
| Empiric Therapy | Dose | Duration |
|---|---|---|
| add Metronidazole | 30mg/kg/d IV div q12h | 7-10 days |
Severely ill
| Empiric Therapy | Duration | |
|---|---|---|
| Meropenem | 60mg/kg/d IV div q8h | 7-10 days |
| + | ||
| Vancomycin | 40-60mg/kg/d IV div q6h |