Enterobacterales, ceftriaxone-resistant (AmpC/ESBL)
| Empiric Therapy |
Intermittent Dosing 1 exchange daily with dwell time at least 6h |
Continuous Dosing (per each L bag) |
Duration |
|---|---|---|---|
| Based on C&S results: | |||
| Meropenem IP |
500mg once per day in long dwell APD 1g once per day in short dwell CAPD |
125mg/L MD |
21 days Strongly recommend catheter removal for refractory peritonitis. Treat for 14 days after catheter removal. |
| or |
|
||
| TMP/SMX | 1DS tab PO bid | 1DS tab PO bid |
21 days Strongly recommend catheter removal for refractory peritonitis. Treat for 14 days after catheter removal. |
| or | |||
| Ciprofloxacin |
500mg PO daily 750mg PO bid for CCPD |
50mg/L MD |
21 days Strongly recommend catheter removal for refractory peritonitis. Treat for 14 days after catheter removal. |
| or | |||
| Gentamicin IP | 0.6mg/kg once per day | Not advised |
21 days Strongly recommend catheter removal for refractory peritonitis. Treat for 14 days after catheter removal. |
APD = automated peritoneal dialysis
CAPD = continuous ambulatory peritoneal dialysis
CCPD = continuous cycling peritoneal dialysis
IP = intraperitoneally
MD = maintenance dose