Adults
Loading Dose
| Antibiotic | Loading Dose mg/kg (IBW) |
|---|---|
| Gentamicin | 2 |
| Tobramycin | 2 |
| Amikacin | 7.5 |
Maintenance Dose
| Antibiotic | Maintenance Dose mg/kg (IBW) per dose |
|---|---|
| Gentamicin | 1.5-2 |
| Tobramycin | 1.5-2 |
| Amikacin | 5-7.5 |
Synergy Dose - Gentamicin & Tobramycin: 1mg/kg (IBW)
- Round doses to nearest 20mg (Gentamicin/Tobramycin)/nearest 25mg (Amikacin).
- Administer over 30 minutes.
Creatinine Clearance (Clcr)
Calculated creatinine clearance (mL/min)
Clcr (females) = [(140 - age) x IBW] divided by Scr (µmol/L)
Clcr (males) = Clcr (female) x 1.2
Dosing Interval Determination for Gentamicin / Tobramycin / Amikacin
| Calculated Clcr (mL/min) | Dosing Interval |
|---|---|
| ≥ 80 | q8h |
| 50-79 | q12h |
| 20-49 | q24h |
| < 20 | Use serum levels to adjust dosing |