Voriconazole has better CSF penetration, however due to significant risks of toxicity and skin cancer, itraconazole or fluconazole may be preferred. Therapeutic drug monitoring (TDM) recommended after 5 days – target trough 2-5µg/mL.
Voriconazole has better CSF penetration, however due to significant risks of toxicity and skin cancer, itraconazole or fluconazole may be preferred. Therapeutic drug monitoring (TDM) recommended after 5 days – target trough 2-5µg/mL.