Neonates < 1 month
- If clinical suspician or LP evidence of meningitis, see Meningitis section.
- If blood or CSF cultures grow Gram negative bacilli within 24 hours, use meropenem empirically.
Usual Pathogens
Group B Streptococci
E. coli
S. aureus/MRSA
Coagulase negative Staph
Less common:
Listeria spp
H. influenzae
Enterococcus spp
Other Enterobacterales
Herpes simplex virus
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Ampicillin | 200mg/kg/d IV div q6h | Reassess at 48h with culture results. |
| + | ||
| [Gentamicin | 4-5mg/kg IV q24h | |
| or | ||
| Cefotaxime] | 200mg/kg/d IV div q6h | |
| +/- | ||
| Acyclovir | 60mg/kg/d IV div q8h |
If MRSA suspected, add:
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Vancomycin | 45mg/kg/d IV div q8h | Reassess at 48h with culture results. |