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Hepatosplenic candidiasis/Chronic disseminated candidiasis

[Clin Infect Dis 2016;62:e1-50.]

- Patients receiving ongoing chemotherapy or stem cell transplantation should continue antifungal therapy throughout high risk period to prevent relapse.

Usual Pathogens

Candida spp

Empiric Therapy	Dose	Duration
Amphotericin B, lipid complex or liposomal	3-5mg/kg IV daily	3-6 months and resolution or calcification of radiologic lesions. Can switch to fluconazole 400mg (6mg/kg) PO daily if patient clinically stable and isolate susceptible.
or
Anidulafungin	200mg IV once then 100mg IV daily	3-6 months and resolution or calcification of radiologic lesions. Can switch to fluconazole 400mg (6mg/kg) PO daily if patient clinically stable and isolate susceptible.
or
Caspofungin	70mg IV once then 50mg IV daily	3-6 months and resolution or calcification of radiologic lesions. Can switch to fluconazole 400mg (6mg/kg) PO daily if patient clinically stable and isolate susceptible.
or
Micafungin	100mg IV daily	3-6 months and resolution or calcification of radiologic lesions. Can switch to fluconazole 400mg (6mg/kg) PO daily if patient clinically stable and isolate susceptible.