Complicated:
-
distal colon surgery
-
ascending cholangitis/hepatic/pancreatic infection
-
prosthetic intravascular device
-
chronic illness
-
immunosuppression
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Piperacillin-tazobactam | 3.375-4.5g IV q6h | See Duration |
Penicillin allergy
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Ceftriaxone | 2g IV daily | See Duration |
| + | ||
| Metronidazole | 500mg IV/PO q12h | |
| +/- | ||
| Vancomycin | 25-30mg/kg IV once then 15mg/kg IV q8-12h |
Cephalosporin allergy
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Ciprofloxacin | 400mg IV q12h/500mg PO bid | See Duration |
| + | ||
| Metronidazole | 500mg IV/PO q12h | |
| + | ||
| Vancomycin | 25-30mg/kg IV once then 15mg/kg IV q8-12h |