Adult Dosing Recommendations in Renal Impairment

  1. Anon.  Renal dosing and insufficiency: Drug dosing considerations In: Sunnybrook [Internet]. Toronto (ON). Ethambutol, Isoniazid, Rifampin, Pyrazinamide [cited 2023 Oct 25]. Available from: https://sunnybrook.ca/content/?page=antimicrobial-stewardship-renal-dialysis
  2. Bains A, Buna D, Hoag NA.  A retrospective review assessing the efficacy and safety of nitrofurantoin in renal impairment.  Can Pharm J 2009;142:248-52.
  3. Bartlett JG.  2002 Pocket book of infectious disease therapy.  12th ed.  Philadelphia, PA:  Lippincott Williams & Wilkins; 2002.
  4. Bennett WM, et al. Drug prescribing in renal failure: Dosing guidelines for adults. 4th ed. Philadelphia, PA: American College of Physicians; 1999.
  5. Canadian Thoracic Society (CTS) of the Canadian Lung Association (CLA) and the Public Health Agency of Canada (PHAC).  Canadian Tuberculosis Standards, 7th Edition, 2013. https://www.respiratoryguidelines.ca/tb-standards-2013
  6. DRUGDEX In: Micromedex [Internet]. Greenwood Village (CO): IBM Watson Health. c1974 – . Ethambutol; [updated 2023 Oct 13; cited 2023 Oct 25]. Available from:  https://www-micromedexsolutions-com.ahs.idm.oclc.org/
  7. Chung C, Bouwmeester C. Nitrofurantoin use in frail, community-dwelling, older adults with renal impairment. Sr Care Pharm. 2019;34(5):303-7.[PubMed 31054588]

  8. Cunha BA, Cunha CB, Lam B, et al. Nitrofurantoin safety and effectiveness in treating acute uncomplicated cystitis (AUC) in hospitalized adults with renal insufficiency: antibiotic stewardship implications. Eur J Clin Microbiol Infect Dis. 2017;36(7):1213-6. doi:10.1007/s10096-017-2911-1[PubMed 28155015]

  9. DRUGDEX In: Micromedex [Internet]. Greenwood Village (CO): IBM Watson Health. c1974 – . Isoniazid; [updated 2023 Oct 13; cited 2023 Oct 25]. Available from:  https://www-micromedexsolutions-com.ahs.idm.oclc.org/

  10. DRUGDEX In: Micromedex [Internet]. Greenwood Village (CO): IBM Watson Health. c1974 – . Rifampin; [updated 2023 Oct 23; cited 2023 Oct 25]. Available from:  https://www-micromedexsolutions-com.ahs.idm.oclc.org/

  11. DRUGDEX In: Micromedex [Internet]. Greenwood Village (CO): IBM Watson Health. c1974 – . Pyrazinamide; [updated 2023 Sep 25; cited 2023 Oct 25]. Available from:  https://www-micromedexsolutions-com.ahs.idm.oclc.org/

  12. Geerts AF, Eppenga WL, Heerdink R, et al. Ineffectiveness and adverse events of nitrofurantoin in women with urinary tract infection and renal impairment in primary care. Eur J Clin Pharmacol 2013;69:1701-7.
  13. Gilbert DN, Moellering RC, Eliopoulos GM, eds.  The Sanford guide to antimicrobial therapy 2017. Sperryville, VA:  Antimicrobial Therapy, Inc. 2017.
  14. Hoang P, Salbu RL.  Updated nitrofurantoin recommendations in the elderly:  a closer look at the evidence.  Consult Pharm 2016;31:381-4.  
  15. Lexi-Drugs In: Lexicomp [Internet]. Hudson, (OH): UpToDate, Inc. c2013 –. Ethambutol; [updated 2023 Oct 23; cited 2023 Oct 25]. Available from: http://online.lexi.com.ahs.idm.oclc.org/lco/action/home

  16. Lexi-Drugs In: Lexicomp [Internet]. Hudson, (OH): UpToDate, Inc. c2013 –. Isoniazid; [updated 2023 Oct 25; cited 2023 Oct 25]. Available from: http://online.lexi.com.ahs.idm.oclc.org/lco/action/home

  17. Lexi-Drugs In: Lexicomp [Internet]. Hudson, (OH): UpToDate, Inc. c2013 –. Rifampin; [updated 2023 Oct 19; cited 2023 Oct 25]. Available from: http://online.lexi.com.ahs.idm.oclc.org/lco/action/home

  18. Lexi-Drugs In: Lexicomp [Internet]. Hudson, (OH): UpToDate, Inc. c2013 –. Pyrazinamide; [updated 2023 Oct 21; cited 2023 Oct 25]. Available from: http://online.lexi.com.ahs.idm.oclc.org/lco/action/home

  19. Mandell GL, Bennett JE, and Dolin R, eds.  Mandell, Douglas and Bennett’s principles & practice of infectious diseases. 7th ed. New York: Churchill Livingstone Inc. 2009.
  20. Oplinger M, Andrews CO.  Nitrofurantoin contraindication in patients with a creatinine clearance below 60 mL/min:  looking for the evidence.  Ann Pharmacother 2013;47:106-11.
  21. Product monographs.  Compendium of Pharmaceuticals and Specialties 2005.
  22. Santos JM, Batech M, Pelter MA, et al. Evaluation of the risk of nitrofurantoin lung injury and its efficacy in diminished kidney function in older adults in a large integrated healthcare system: a matched cohort study. J Am Ger Soc. 2016;64(4):798-805. doi:10.1111/jgs.14072 [PubMed 27100576]
  23. Singh N, Gandhi S, McArthur E, et al.  Kidney function and the use of nitrofurantoin to treat urinary tract infections in older women.  CMAJ 2015;187:648-56.