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Complicated UTI/Males

Usual Pathogens

E. coli
Other Enterobacterales
Enterococcus spp
S. agalactiae (Group B Strep)
P. aeruginosa
Corynebacterium urealyticum
Aerococcus urinae
Actinobaculum spp
Actinomyces turicensis

Lower urinary tract and afebrile, systemically well

Empiric Therapy	Dose	Duration
Cefixime	400mg PO daily	7-10 days
or
Amoxicillin-clavulanate	875mg PO bid	7-10 days
or
Ciprofloxacin	500mg PO bid or	7 days
	XL 1g PO daily	7 days
or
TMP/SMX	1DS tab PO bid	7-10 days

Upper urinary tract and/or febrile, systemically unwell

Empiric Therapy	Dose	Duration
Ampicillin	1-2g IV q6h	7 days
+
[Ceftriaxone	1-2g IV daily
or
Gentamicin]	5-7mg/kg IV q24h

Septic/Hemodynamically unstable

Empiric Therapy	Dose	Duration
Piperacillin-tazobactam	3.375g IV q6h	7 days
+/-
Gentamicin	5-7mg/kg IV q24h