Extracutaneous
Usual PathogensSporothrix schenckii
Sporothrix spp, other
Osteoarticular
| Empiric Therapy | Duration | |
|---|---|---|
| Itraconazole | 200mg PO bid | 12 months |
Pulmonary - severe
| Empiric Therapy | Duration | |
|---|---|---|
| Amphotericin B | 0.7-1mg/kg IV daily | Until response then switch to itraconazole 200mg PO bid for total of 12 months |
| Alternative | ||
| Amphotericin B, lipid complex | 3-5mg/kg IV daily | Until response then switch to itraconazole 200mg PO bid for total of 12 months |
| or | ||
| Amphotericin B, liposomal | 3-5mg/kg IV daily | Until response then switch to itraconazole 200mg PO bid for total of 12 months |
Pulmonary - mild to moderate
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Itraconazole | 200mg PO bid | 12 months |
Meningeal or disseminated
| Empiric Therapy | Duration | |
|---|---|---|
| Amphotericin B | 0.7-1mg/kg IV daily | Until response (4-6 weeks) then switch to itraconazole 200mg PO bid for total of 12 months |
| Alternative | ||
| Amphotericin B, liposomal | 3-5mg/kg IV daily | Until response (4-6 weeks) then switch to itraconazole 200mg PO bid for total of 12 months |
Pregnant
| Empiric Therapy | Duration | |
|---|---|---|
| Amphotericin B | 0.7-1mg/kg IV daily | 12 months |
| Alternative | ||
| Amphotericin B, liposomal | 3-5mg/kg IV daily | 12 months |
| or | ||
| Amphotericin B, lipid complex | 3-5mg/kg IV daily | 12 months |