Usual Pathogens
Pneumocystis jirovecii
Mild to Moderate PJP
| Empiric Therapy | Dose | Duration |
|---|---|---|
| TMP/SMX | 2DS tab PO q8h | 21 days |
Alternative
| Empiric Therapy | Dose | Duration |
|---|---|---|
| [Trimethoprim | 15mg/kg/day PO div tid | 21 days |
| + | ||
| Dapsone] | 100mg PO daily | |
| or | ||
| [Clindamycin PO | 450mg PO qid | 21 days |
| + | ||
| Primaquine] | 30mg base PO daily | |
| or | ||
| Atovaquone susp | 750mg PO bid with food | 21 days |
Moderate to Severe PJP
| Empiric Therapy | Dose | Duration |
|---|---|---|
| TMP/SMX |
2DS tab PO q8h or 15-20mg TMP/kg/day IV div q8h |
21 days |
Alternative
| Empiric Therapy | Duration | |
|---|---|---|
| [Clindamycin IV/PO | 900mg IV q8h/450mg PO qid | 21 days |
| + | ||
| Primaquine] | 30mg base PO daily | |
| or | ||
| Pentamidine | 4mg/kg IV daily | 21 days |
PLUS if indicated
Adjunctive Oral Corticosteroid
| Empiric Therapy | Duration | |
|---|---|---|
| Prednisone | 40mg PO bid | 5 days |
| then | ||
| Prednisone | 40mg PO daily | 5 days |
| then | ||
| Prednisone | 20mg PO daily | 11 days |
or
Adjunctive Parenteral Corticosteroid
| Empiric Therapy | Duration | |
|---|---|---|
| Methylprednisolone | 30mg IV bid | 5 days |
| then | ||
| Methylprednisolone | 30mg IV daily | 5 days |
| then | ||
| Methylprednisolone | 15mg IV daily | 11 days |