Intraoperative Antibiotic Administration
Intraoperative repeat dosing is recommended if:
-
prolonged surgical procedure (> 2 half-lives of the antimicrobial), or
-
major blood loss (> 1.5L)
Prophylactic Antibiotic | Recommended Intraoperative redosing interval (from time of administration of pre-op dose): |
---|---|
Cefazolin | q4h (q3h with cardiopulmonary bypass) |
Cefuroxime | q4h |
Clindamycin | q4h |
Levofloxacin | q12h |
Metronidazole | q8h |
Vancomycin | q8h |