From Sinusitis

 

Usual Pathogens
Polymicrobial:

Streptococcus pneumoniae
M. catarrhalis

S. aureus/MRSA

H. influenzae

Anaerobes

 

Empiric Therapy

Dose

Duration
Surgical drainage    
+    
Ceftriaxone 1g IV daily 14-21 days
+    
Metronidazole 500mg IV q12h  
+    
Vancomycin 15mg/kg IV q12h  

Ceftriaxone allergy

Empiric Therapy

Dose

Duration
Levofloxacin

750mg IV daily

14-21 days
+    
Metronidazole 500mg IV q12h  
+    
Vancomycin 15mg/kg IV q12h