Ceftolozane-tazobactam

Predictable Activity

Escherichia coli
Haemophilus influenzae
Haemophilus parainfluenzae
Klebsiella oxytoca
Moraxella catarrhalis
Proteus mirabilis
Pseudomonas aeruginosa

Unpredictable Activity

Aerobic Gram negative bacilli – nonfermenters
Bacteroides fragilis group
ß-haemolytic Streptococci (Group A,B,C,G)
Citrobacter koseri
Klebsiella pneumoniae
Morganella morganii
Proteus vulgaris complex
Providencia spp
Pseudomonas spp (other than P. aeruginosa)
Raoultella spp
Serratia spp
Streptococcus anginosus group
Streptococcus pneumoniae (Pen-S)

No/Insufficient Activity

Acinetobacter spp
Anaerobes (except Bacteroides fragilis group)
Burkholderia spp
Chlamydia spp
Citrobacter freundii complex
Coagulase negative Staphylococci (CoNS)
Enterobacter spp
Enterobacterales with some ESBLs and carbapenemase
Enterococcus spp
Klebsiella spp with ESBL
Listeria monocytogenes
Mycoplasma spp
Pseudomonas aeruginosa with carbapenemase
Staphylococcus spp (MSSA, MRSA)
Staphylococcus lugdunensis
Stenotrophomonas maltophilia
Streptococcus pneumoniae (Pen-I, Pen-R)
Viridans group Streptococci