Low risk

[Pediatrics 2010;125:228-33]

- Recommend:

• CBC

• CRP

• blood cultures

• catheter/suprapubic urine.

Lumber puncture (LP) should be considered in infants with sepsis without a focus.

- Watchful waiting with no empiric antibiotic therapy may be considered for low risk infants if ALL of the following criteria are met:

• previously healthy – term, uncomplicated perinatal course, no chronic illness or surgery, no prior antibiotics

• no focal bacterial infection on exam (including no otitis media)

• non-toxic – no lethargy, good perfusion, normal respiratory rate, no cyanosis, feeding well

• negative laboratory screen – WBC 5-15 x 10⁹/L, CRP < 20mg/L, urinalysis < 10 WBC/hpf

• parents are reliable and close follow-up is assured.

Group B Streptococci
E. coli
S. pneumoniae
N. meningitidis

H. influenzae