Shoulder arthroplasty, rotator cuff surgery

- For positive cultures, see Treatment of Culture-proven Prosthetic Joint Infections.

- Debridement of all necrotic tissue and removal of all nonabsorbable sutures and implants is recommended. Consider adding rifampin 300mg PO bid for Staph infections if hardware cannot be removed.

 
Usual Pathogens

C. acnes
S. aureus

 
Occasionally:

Polymicrobial

 

Empiric Therapy Dose Duration
Vancomycin 15mg/kg IV q12h 4-6 weeks

Documented C. acnes infection

Empiric Therapy Dose Duration
Penicillin 4MU IV q4h 4-6 weeks
or    
Ceftriaxone 2g IV daily 4-6 weeks