Antimicrobial Prophylaxis for Preterm (< 37 weeks gestation) Rupture of Membranes
- In the asymptomatic stable patient with preterm rupture of membranes, prophylaxis with one of the following regimens is recommended:
| Antimicrobial Regimen | Dose & Duration |
|---|---|
| Azithromycin | 1g PO once only |
| + | |
| Ampicillin | 2g IV q6h x 48 hours |
| Followed by: | |
| Amoxicillin | 500mg PO tid x 5 days |
Penicillin/amoxicillin allergy
| Antimicrobial Regimen | Dose & Duration |
|---|---|
| Azithromycin | 1g PO once only |
| + | |
| Cefazolin | 2g IV once then |
| 1g IV q8h x 5 doses |
Penicillin and cefazolin allergy or severe non IgE-mediated reaction to any β-lactam
| Antimicrobial Regimen | Dose & Duration |
|---|---|
| Azithromycin | 1g PO once only |
| + | |
| Vancomycin | 20mg/kg (max 2g) IV q8h x 48 hours |