Post trauma or post operative
- Send CSF for aerobic and anaerobic culture.
- If no previous antibiotic therapy, no foreign material, and negative CSF cultures, can discontinue antibiotic therapy at 72 hours.
Usual Pathogens
S. pneumoniae
S. aureus/MRSA
S. epidermidis
Enterobacterales
P. aeruginosa
Cutibacterium acnes (if foreign material)
| Empiric Therapy | Dose | Duration |
|---|---|---|
|
[Ceftazidime |
2g IV q8h | 10-14 days |
| or | ||
| Meropenem] | 2g IV q8h | |
| + | ||
| Vancomycin | 15mg/kg IV q8-12h |
Alternative if ceftazidime or carbapenem allergy or resistance
| Empiric Therapy | Dose | Duration |
|---|---|---|
| 15mg/kg IV q8-12h | 10-14 days | |
| + | ||
| Ciprofloxacin | 400mg IV q8-12h |