S. pneumoniae
- Early surgical intervention often required.
Penicillin MIC ≤ 0.12µg/mL
| Therapy | Dose | Duration | |
|---|---|---|---|
| Native | Prosthetic | ||
| Penicillin | 3MU IV q4h | 4 weeks | 6 weeks |
| or | |||
| Ceftriaxone | 2g IV daily | 4 weeks | 6 weeks |
Penicillin MIC > 0.12 - 2.0µg/mL
| Therapy | Dose | Duration | |
|---|---|---|---|
| Native | Prosthetic | ||
| 4 weeks | 6 weeks | ||
Ceftriaxone MIC ≥ 2.0µg/mL
| Therapy | Dose | Duration | |
|---|---|---|---|
| Native | Prosthetic | ||
| Ceftriaxone | 2g IV daily | 4 weeks | 6 weeks |
| + | |||
| Vancomycin | 15mg/kg IV q8-12h | 4 weeks | 6 weeks |
| + | |||
| Rifampin | 300mg PO bid | 4 weeks | 6 weeks |
Severe penicillin/cephalosporin allergy
| Therapy | Dose | Duration | |
|---|---|---|---|
| Native | Prosthetic | ||
| 15mg/kg IV q8-12h | 4 weeks | 6 weeks | |