Severe
- > 6 diarrheal episodes/day
- bloody diarrhea
- persistent (> 3 days) diarrhea
- fever
- Culture recommended.
- Tailor antibiotics to C&S results.
Usual Pathogens
diarrheagenic E. coli
Campylobacter spp
Shigella spp
Enterotoxigenic Bacteroides fragilis
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Azithromycin | 1g PO or | 1 dose |
| 500mg PO daily | 3 days | |
| or | ||
| Levofloxacin | 500mg PO or | 1 dose |
| 500mg PO daily | 3 days | |
| or | ||
| Norfloxacin | 800mg PO or | 1 dose |
| 400mg PO bid | 3 days | |
| or | ||
| Ciprofloxacin | 750mg PO or | 1 dose |
| 500mg PO bid | 3 days | |
| or | ||
| TMP/SMX | 2 DS tabs PO or | 1 dose |
| 1 DS tab PO bid | 3 days |