Cefazolin Lack of Cross-Reactivity References:
- Uyttebroek et al. J Allergy Clin Immunol Pract 2016;4(6):1232-6 (lack of skin sensitivity between cephalosporins including cefazolin).
- Blumenthal et al. Antimicrob Agents Chemother 2014;58(6):3137-43 (cefazolin fine with nafcillin allergy).
- Romano et al. J Allergy Clin Immunol 2015;136(3):685-91 (via drug-specific assays/challenge testing distinction between cephalosporins including cefazolin).
- Zagursky et al. J Allergy Clin Immunol Pract 2018;6(1):72-81 (great review article that summarizes cefazolin cross-reactivity/skin-reactivity data - highlight essentially no true cross-reactivity)
The review by Zagursky et al includes the below as citations:
Varela et al. J Investig Allergol Clin Immunol 2009;19:164-5. (cefuroxime against other cephalosporins, including cefazolin).
Montanez et al. Chem Res Toxicol 2011;24:706-17. (antigenic determinants of cephalosporin allergies).
Somech et al. Int Arch Allergy Immunol 2009;150:205-9. (skin-testing challenge testing with different cephalosporins).
Tuyls et al. J Allergy Clin Immunol 2016;137:331.
Pipet et al. A statement on cefazolin immediate hypersensitivity: data from a large database, and focus on the cross-reactivities. Clin Exp Allergy 2011;41:1602-8.
Cefuroxime references for cross-reactivity:
- Antunez et al. J Allergy Clin Immunol 2006;117(2):404-10.
- Hasdenteufel et al. Ann Pharmacother 2007;41:1069-72.
Clavulanate reference: Blanca-Lopez et al. Allergy 2015;70(8):1013-9.
Tazobactam reference: Rank M et al. Anaphylaxis to piperacillin-tazobactam despite a negative penicillin skin-test. Allergy: Europ J Allergy Clin Immunol 2007;62(8):964-5.