Epidural abscess
- Infectious complication of:
- endocarditis
- vertebral osteomyelitis
- psoas muscle abscess.
Diagnosis
- Symptoms:
- back/neck (cervical) pain
- neurologic deficit (motor weakness, radiculopathy, bladder/bowel dysfunction)
- fever
- MRI – emergent if progressive neurological deficit
- Blood cultures
- Usually requires urgent surgical intervention. Medical therapy alone may be considered if the patient is not a surgical candidate AND has no neurologic deficit and/or shows improvement in symptoms.
- Treat according to C&S results of blood cultures or CT-guided aspirate of abscess. If cultures are positive for Gram positive cocci in clusters/clumps, use vancomycin + cloxacillin until susceptibilities available.
Usual Pathogens
S. aureus/MRSA
Enterobacterales
Streptococcus spp
CoNS
P. aeruginosa
Rare:
Anaerobes
Consider:
- TB, depending on epidemiology
- Candida/fungal if spinal instrumentation or injection
Empiric Therapy | Dose | Duration |
---|---|---|
Vancomycin | 15mg/kg IV q8-12h | 6 weeks |
+ | ||
Ceftriaxone | 2g IV q12h |