Prophylaxis of Dental Procedures in Immunocompromised Patients
- The risk of sepsis following dental procedures in immunocompromised patients should not be much higher than the general population.
- Certain conditions that may be associated with increased risk of infection include but are not limited to: neutropenia and neutrophil dysfunction, severe malnourishment, poorly controlled diabetes, and certain haematologic malignancies/disorders.
For these conditions recommend:
| Antibiotic | Adult Dose | Paediatric Dose |
|---|---|---|
| amoxicillin | 2g PO x 1 dose 30-60 min before | 50 mg/kg (max 2g) PO x 1 dose 30-60 min before |
| Penicillin/amoxicillin allergy | ||
| cefuroxime axetil |
500mg PO x 1 dose 30-60 min before | 10mg/kg (max 500mg) PO x 1 dose 30-60 min before |
| Cefuroxime allergy | ||
| azithromycin |
500mg PO x 1 dose 30-60 min before | 15mg/kg (max 500mg) PO x 1 dose 30-60 min before |
| or | ||
| clarithromycin | 500mg PO x 1 dose 30-60 min before | 15mg/kg (max 500mg) PO x 1 dose 30-60 min before |
| or | ||
| doxycycline | 100mg PO x 1 dose 30-60 min before | < 45 kg: 2.2mg/kg PO x 1 dose 30-60 min before |
> 45 kg: 100mg PO x 1 dose 30-60 min before |
||