Tetracyclines/Glycylcycline
| Antimicrobial | Dosage Adjustment |
|---|---|
| Doxycycline | No change necessary |
| Minocycline | Significant excretion via biliary tract. No accumulation noted with hepatic impairment. No change necessary |
| Tetracycline | Do not use with severe hepatic impairment |
| Tigecycline | No change necessary in patients with mild to moderate (Child Pugh A or B) impairment. Severe (Child Pugh C) hepatic impairment: 100mg IV x 1 dose then 25mg IV q12h. |