IV to PO Switch Recommendations

Parenteral Regimen	Cost($)/Day	Oral Regimen	Cost($)/Day	Bioavailability(%)
Amoxicillin-clavulanate 1000mg-200mg IV q6-8h or 2000mg-200mg IV q8-12h	65.37-87.16 65.36-98.04	Amoxicillin-clavulanate 875mg bid	1.11	Amoxicillin 80%; clavulanate 30-98%
Azithromycin 500mg daily	21.69	Azithromycin 500mg daily	1.88	37
Cefazolin 1g q8h	9.69	Cephalexin 500mg q6h	0.69	90
Cefuroxime 0.75-1.5g q8h	70.53-141.16	Cefuroxime axetil 0.5-1g q12h	2.87-5.73	52
Genitourinary tract infections:
Ciprofloxacin 200mg q12h	33.88	Ciprofloxacin 250-500mg q12h	0.89-1.01	70
Nosocomial pneumonia, Gram negative bone/joint infections:
Ciprofloxacin 400mg q12h	66.16	Ciprofloxacin 500-750mg q12h	1.01-1.84	70
Clindamycin 600mg q8h	45.36	Clindamycin 300mg q6h Bone/joint infections: 450mg q6h	1.77 2.66	90
Fluconazole 400mg daily	81.70	Fluconazole 400mg daily	9.16	90
Isavuconazole 200mg q8h x 6 doses then 200mg daily	1200.00 400.00	Isavuconazole 200mg q8h x 6 doses then 200mg daily	472.98 157.66	98
Levofloxacin 250-750mg daily	31.82-57.38	Levofloxacin 250-750mg daily	1.20-4.85	99
Linezolid 600mg q12h	177.48	Linezolid 600mg q12h	74.10	100
Metronidazole 500mg q12h	5.42	Metronidazole 500mg q12h	0.27	100
Moxifloxacin 400mg daily	41.08	Moxifloxacin 400mg daily	1.52	89
Trimethoprim-sulfamethoxazole 160/800mg q8h	53.17	Trimethoprim-sulfamethoxazole 1 DS tab q12h	0.41	85
Voriconazole 400mg q12h x 2 doses then 200mg q12h	546.32 273.16	Voriconazole 400mg q12h x 2 doses then 200mg q12h	105.92 52.96	96