Macrolides
| Antimicrobial | Normal Adult Dose | Dose and Interval Adjustment for Renal Impairment | ||
|---|---|---|---|---|
| Creatinine Clearance (mL/min) | ||||
| >50 | 10 - 50 | <10 (Anuric) | ||
| Erythromycin | 250-500mg PO q6h | NO CHANGE NEEDED | 50-75% dose q6h | |
| 0.5-1g IV q6h | NO CHANGE NEEDED | 50-75% dose q6h | ||
| Azithromycin | 250-500mg PO daily | NO CHANGE NEEDED | unknown | |
| 500mg IV daily | NO CHANGE NEEDED | unknown | ||
| Clarithromycin | 250-500mg PO q12h | q12h | q12-24h | q24h |
| Clarithromycin XL | XL 1000mg PO daily | > 30mL/min: NO CHANGE NEEDED | < 30mL/min: 500mg daily | |