Ceftobiprole

Predictable Activity

Anaerococcus spp
ß-haemolytic Streptococci (Group A,B,C,G)
Coagulase negative Staphylococci (CoNS)
Cutibacterium acnes
Enterococcus spp (ampicillin susceptible)
Escherichia coli (non-ESBL)
Finegoldia spp
Haemophilus influenzae
Haemophilus parainfluenzae
Klebsiella spp (non-ESBL)
Micromonas spp
Moraxella catarrhalis
Neisseria spp
Peptoniphilus spp
Peptostreptococcus spp (except P. anaerobius)
Proteus mirabilis (non-ESBL)
Pseudomonas aeruginosa (activity better than cefepime, similar to ceftazidime)
Salmonella spp
Staphylococcus aureus (MSSA, MRSA, VISA, VRSA)
Streptococcus anginosus group
Streptococcus pneumoniae (Pen-S, Pen-I, Pen-R)
Viridans group Streptococci

Unpredictable Activity

Acinetobacter spp
Actinomyces spp
Citrobacter spp
Clostridium spp
Enterobacter spp
Fusobacterium spp
Listeria monocytogenes
Morganella spp
Peptostreptococcus anaerobius
Porphyromonas spp
Proteus vulgaris complex (P. vulgaris, P. hauseri. P. penneri)
Providencia spp
Serratia spp

No/Insufficient Activity

Acinetobacter spp (imipenem-resistant)
Anaerobic Gram negative bacilli
Bacteroides fragilis group
Burkholderia cepacia complex
Chlamydia spp
Chryseobacterium spp
Clostridioides (Clostridium) difficile
Corynebacterium spp
Enterococcus spp (ampicillin-resistant)
Enterobacterales producing ESBLs
Lactobacillus spp
Legionella spp
Leuconostoc spp
Mycobacteria
Mycoplasma spp
Nocardia spp
Pediococcus spp
Prevotella spp
Pseudomonas aeruginosa (ceftazidime-resistant)
Stenotrophomonas maltophilia
Streptococcus pneumoniae (ceftriaxone-resistant)