Initial episode - nonsevere
WBC < 15 x 109/L,
andserum creatinine < 130 umol/L
Clostridioides difficile
Low Risk
| Empiric Therapy | Duration | |
|---|---|---|
| Metronidazole | 500mg PO/NG tid | 10 days |
If NPO for oral medications
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Metronidazole IV | 500mg IV q8h | 10 days |
Allergy/intolerance/unresponsive to metronidazole
| Empiric Therapy | Duration | |
|---|---|---|
| Vancomycin | 125mg PO/NG qid |
High risk
| Empiric Therapy | Duration | |
|---|---|---|
| Vancomycin | 125mg PO/NG qid |
Vancomycin allergy/intolerance
| Empiric Therapy | Duration | |
|---|---|---|
| Fidaxomicin | 200mg PO bid |