Coagulase negative Staph, S. epidermidis
| Therapy |
Dose |
Duration |
| Cloxacillin susceptible |
|
|
| Cloxacillin |
2g IV q4h |
6 weeks |
| or |
|
|
| Cefazolin |
2g IV q8h |
6 weeks |
| Cloxacillin resistant |
|
|
| Vancomycin |
15mg/kg IV q8-12h |
6 weeks |
Prosthetic Valve
| Therapy |
Dose |
Duration |
| Cloxacillin susceptible |
|
|
| [Cloxacillin |
2g IV q4h |
≥ 6 weeks |
| or |
|
|
| Cefazolin] |
2g IV q8h |
|
| + |
|
|
| Gentamicin |
3mg/kg IV daily |
2 weeks |
| + |
|
|
| Rifampin |
300mg PO tid or |
≥ 6 weeks |
| |
600mg PO bid |
|
| Cloxacillin resistant |
|
|
Vancomycin |
15mg/kg IV q8-12h |
≥ 6 weeks |
| + |
|
|
Gentamicin |
3mg/kg IV daily |
2 weeks |
| + |
|
|
Rifampin |
300mg PO tid or |
≥ 6 weeks |
| |
600mg PO bid |
|
