Polymicrobial skin & soft tissue, Severe Immunosuppression / Neutropenia
groin/peri-rectal cellulitis/Fournier’s gangrene
progressive diabetic wound
severe bite/traumatic wounds
- Recommend urgent surgical/ID consult.
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Piperacillin-tazobactam | 3.375g-4.5g IV q6h | 7-14 days |
| + | ||
| Vancomycin | 25-30mg/kg IV once then 15mg/kg IV q8-12h |
Penicillin allergy/anaphylaxis
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Vancomycin | 25-30mg/kg IV once then 15mg/kg IV q8-12h | 7-14 days |
| + | ||
| Ciprofloxacin | 400mg IV q12h | |
| + | ||
| Metronidazole | 500mg IV q12h |