Intravascular Catheter
- Line must be removed if any of:
- tunnel infection
- failure to respond within 72 hours (persistent positive daily blood cultures)
- fungal (with a percutaneous CVL).
Coagulase negative Staph (CoNS)
S. aureus
S. lugdunensis
Enterobacterales
| Empiric Therapy | Dose | Duration |
|---|---|---|
| [Cefazolin | 100mg/kg/d IV div q8h | See Duration |
| or | ||
| Cloxacillin] | 200mg/kg/d IV div q6h | |
| + | ||
| [Gentamicin | 7mg/kg IV q24h | |
| or | ||
| Tobramycin] | 7mg/kg IV q24h |
Candida spp
- Line removal recommended if at all possible.
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Amphotericin B | 0.6-1mg/kg IV daily | 14 days after first negative BC |
| or | ||
| Fluconazole | 12mg/kg/d IV/PO div q12h | 14 days after first negative BC |