Switch to oral agent when:

• resolution of systemic symptoms

• no further progression of cellulitis.

Total duration depends on response to therapy. Reassess at 3 days for potential switch to oral therapy. Treat for 10 days if risk of treatment failure:

• overlying joint involvement

• chronic leg ulcers

• chronic edema/lymphedema

• obesity (BMI >40)

• prior cellulitis in same area.